Ancestry Specific variation in neuropsychological disorders among the South Asian population

The enormous genetic diversity in South Asia resulting from a long and complex admixture history resulted the emergence of variation various traits variations disease susceptibility. Neuropsychological disorders are one such example that shows at population level. In this study, we aimed understanding neuropsychological level among Asian populations by curating, comparing contrasting single nucleotide polymorphisms (SNPs), known to be associated with same. Whole-genome data comprising 1662 Asians, belonging 241 distinct were obtained database Dr. David Reich, Harvard Medical School, USA. Principal Component Analysis (PCA) revealed Ancestral Tibeto Burman (ATB) genomes form distinguishable cluster for SNPs disorders. Identical By Descent (IBD) analysis showed out top seven terms IBD sharing, six Southern India indicating these may have undergone recent selective sweep SNPs. Further, ten genomes, according number fixed minor alleles, India. Furthermore, several indigenous depicted high F values (>0.25) disorders, higher susceptibility Indian populations. Interestingly, found most SNPs, alternative also ancient Indus Valley Civilization (IVC), likely got transmitted modern-day IVC.